Total neutral 17-ketosteroids; clinical method for measurement.

The Determination of the Total Neutral 17-Ketosteroids in Urine.

THE COLORIMETRIC ASSAY OF TOTAL, a-, AND p-17- KETOSTEROIDS IN EXTRACTS OF HUMAN URINE*

The present paper reports a method for determining the respective concentrations of total, o(-, and /3-17-ketosteroids in urine which is based upon the previously reported method of assaying mixtures of crystalline androsterone (a-steroid) and dehydroisoandrosterone (p-steroid) (1) and a simple means of eliminating the interfering effect of the non-ketonic substances from the calorimetric deter...

The Neutral 17-Ketosteroids in Rheumatoid Arthritis and Spondylitis.

Sjovall (1944), studying the excretion of folliclestimulating hormone, found that 21 per cent. of female patients under the age of 40 years suffering from rheumatoid arthritis showed evidence of pituitary-ovarian dysfunction. Davison and others (1947) found no significant alteration in the excretion of 17-ketosteroids in eleven female patients with rheumatoid arthritis, but reported an increase...

A Quantitative Study of the Urinary Excretion of Hypophyseal Gonadotropin, Estrogen, and Neutral 17-ketosteroids of Normal Men.

The urinary output of hypophyseal gonadotropin by normal women has proven exceedingly variable from month to month (1, 2). Thus, the usefulness of gonadotropin assays for clinical purposes has been disappointing and is now limited to the demonstration of large excesses of hormone. The status of the gonadotropin assay as a potential diagnostic measure in men is still in doubt. More normal data a...

Test-tube extraction method for the micro-determination of urinary 17-ketosteroids.

SIMPLE, RAPID TEST-TUBE EXIRACTION TECHNIC for the determination of urinary 17-ketosteroids has seen developed in our laboratories. A complete urinary 17-ketosteroid determination was carried out in a glass stoppered photometer cuvet by combining this extraction technic with a colorimetric method. Three colorimetric methods, Zimmermann (1), (2), Pincus (3), and Cohen and Kaluszyner (4) were com...